Shirai T, Sano M, Tamano S, Takahashi S, Hirose M, Futakuchi M, Hasegawa R, Imaida K, Matsumoto K, Wakabayashi K, Sugimura T, Ito N
First Department of Pathology, Nagoya City University Medical School, Muzuho-cho, Mizuho-ku, Japan.
Cancer Res. 1997 Jan 15;57(2):195-8.
Prostate tissues obtained from rats given a food-derived carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), at a dose of 400 ppm in the diet for 52 weeks were histopathologically evaluated and found to contain prostate carcinomas limited to the ventral lobe in 18 of 27 cases. Atypical hyperplasias were also detected in the ventral and anterior prostate as well as the seminal vesicles. 32P-Postlabeling analysis of DNA demonstrated that PhIP-DNA adducts are produced in all lobes of the prostate of rats receiving PhIP. The findings indicate that PhIP is carcinogenic to rat prostate in addition to the previously demonstrated targeting of the colon and mammary glands, providing evidence of a possible role of PhIP in human prostate carcinogenesis and highlighting the potential importance of PhIP for man.
给大鼠喂食剂量为400 ppm的食物源性致癌物2-氨基-1-甲基-6-苯基咪唑并[4,5-b]吡啶（PhIP），持续52周后获取前列腺组织，进行组织病理学评估，结果发现，27例中有18例的前列腺癌局限于腹叶。在腹侧前列腺、前叶前列腺以及精囊中也检测到了非典型增生。对DNA进行32P后标记分析表明，接受PhIP的大鼠前列腺所有叶中均产生了PhIP-DNA加合物。这些发现表明，除了先前证明的对结肠和乳腺的靶向作用外，PhIP对大鼠前列腺具有致癌性，这为PhIP在人类前列腺癌发生中的可能作用提供了证据，并突出了PhIP对人类的潜在重要性。
