Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.
Am J Clin Nutr. 2010 Mar;91(3):712-21. doi: 10.3945/ajcn.2009.28474. Epub 2009 Dec 30.
Processed meat and fish have been shown to be associated with the risk of advanced prostate cancer, but few studies have examined diet after prostate cancer diagnosis and risk of its progression.
We examined the association between postdiagnostic consumption of processed and unprocessed red meat, fish, poultry, and eggs and the risk of prostate cancer recurrence or progression.
We conducted a prospective study in 1294 men with prostate cancer, without recurrence or progression as of 2004-2005, who were participating in the Cancer of the Prostate Strategic Urologic Research Endeavor and who were followed for an average of 2 y.
We observed 127 events (prostate cancer death or metastases, elevated prostate-specific antigen concentration, or secondary treatment) during 2610 person-years. Intakes of processed and unprocessed red meat, fish, total poultry, and skinless poultry were not associated with prostate cancer recurrence or progression. Greater consumption of eggs and poultry with skin was associated with 2-fold increases in risk in a comparison of extreme quantiles: eggs [hazard ratio (HR): 2.02; 95% CI: 1.10, 3.72; P for trend = 0.05] and poultry with skin (HR: 2.26; 95% CI: 1.36, 3.76; P for trend = 0.003). An interaction was observed between prognostic risk at diagnosis and poultry. Men with high prognostic risk and a high poultry intake had a 4-fold increased risk of recurrence or progression compared with men with low/intermediate prognostic risk and a low poultry intake (P for interaction = 0.003).
Our results suggest that the postdiagnostic consumption of processed or unprocessed red meat, fish, or skinless poultry is not associated with prostate cancer recurrence or progression, whereas consumption of eggs and poultry with skin may increase the risk.
已证实加工肉类和鱼类与晚期前列腺癌的风险相关，但很少有研究检查前列腺癌诊断后的饮食与疾病进展风险之间的关系。
我们研究了诊断后食用加工和未加工的红肉、鱼类、家禽和蛋类与前列腺癌复发或进展风险之间的关联。
我们对 1294 名前列腺癌患者进行了前瞻性研究，这些患者在 2004-2005 年时没有复发或进展，他们参与了癌症前列腺战略泌尿科研究努力，并平均随访了 2 年。
我们观察到在 2610 人年中发生了 127 例事件（前列腺癌死亡或转移、前列腺特异性抗原浓度升高或二次治疗）。加工和未加工的红肉、鱼类、总家禽和去皮家禽的摄入量与前列腺癌复发或进展无关。在极端分位数比较中，鸡蛋和带皮家禽的摄入量与风险增加 2 倍相关：鸡蛋[风险比（HR）：2.02；95%置信区间（CI）：1.10，3.72；趋势 P 值=0.05]和带皮家禽（HR：2.26；95% CI：1.36，3.76；趋势 P 值=0.003）。在诊断时的预后风险与家禽之间观察到交互作用。具有高预后风险和高家禽摄入量的男性与具有低/中预后风险和低家禽摄入量的男性相比，复发或进展的风险增加了 4 倍（交互作用 P 值=0.003）。
我们的结果表明，诊断后食用加工或未加工的红肉、鱼类或去皮家禽与前列腺癌复发或进展无关，而食用鸡蛋和带皮家禽可能会增加风险。
