Kleinschmidt J J, Digre K B, Hanover R
Department of Ophthalmology, University of Utah Health Sciences, Center, Salt Lake City, USA.
Neurology. 2000 Jan 25;54(2):319-24. doi: 10.1212/wnl.54.2.319.
To explore the incidence of depression and anxiety and to measure quality of life in women with idiopathic intracranial hypertension (IIH), a matched group cross-sectional study was conducted. Women with IIH (n = 28) were compared with control groups of weight- and age-matched women not diagnosed with IIH (n = 30) and with age-matched women of normal weight (n = 30).
Eighty-eight women completed a questionnaire soliciting health information and standardized questionnaires measuring depression, anxiety, and quality of life. The groups were compared using analysis of variance and chi2 tests. Where appropriate, post hoc comparisons were made using Fisher's test.
Patients with IIH reported a greater number of adverse health problems than either of the control groups. Non-health-related psychosocial concerns were equally prevalent among the three groups, but IIH patients were significantly more affected by hardships associated with health problems than the other two groups. The patient group also had higher levels of depression and anxiety than the control groups. These adverse health conditions were reflected in decreased quality of life measures for the IIH patients.
This study supports previous reports that link obesity and psychosocial difficulties, but obesity alone is not the explanation for the higher levels of depression and lower levels of quality of life.
为探讨特发性颅内高压（IIH）女性患者的抑郁和焦虑发生率，并评估其生活质量，开展了一项匹配组横断面研究。将IIH女性患者（n = 28）与体重和年龄匹配的未诊断为IIH的女性对照组（n = 30）以及年龄匹配的正常体重女性对照组（n = 30）进行比较。
88名女性完成了一份征求健康信息的问卷以及测量抑郁、焦虑和生活质量的标准化问卷。使用方差分析和卡方检验对各组进行比较。在适当情况下，使用Fisher检验进行事后比较。
IIH患者报告的不良健康问题比两个对照组中的任何一组都多。与健康无关的社会心理问题在三组中同样普遍，但IIH患者比其他两组更受与健康问题相关的困难影响。患者组的抑郁和焦虑水平也高于对照组。这些不良健康状况反映在IIH患者生活质量指标的下降上。
本研究支持先前将肥胖与社会心理困难联系起来的报告，但仅肥胖并不能解释较高的抑郁水平和较低的生活质量水平。
