Löcsey L, Szlanka B, Ménes I, Kövér A, Vitai E, Malkócs Z, Keresztes P, Paragh G
Euro-Care Dialysis Centre No. 10, 1st Department of Medicine, Kenézy Gyula Hospital, Debrecen, Hungary.
Int Urol Nephrol. 1999;31(4):547-55. doi: 10.1023/a:1007131815673.
The authors performed bioimpedance analysis and Cardio Tens (24-h ABPM and ECG) monitoring in 66 patients (28 males, 38 females) treated in the chronic haemodialysis programme. They investigated the correlations between the body weights before, during and after dialysis, the changes of the water compartments and fat body weight, and the recorded values of blood pressure and ECG alterations. On the basis of the measurements by this non-invasive method it is concluded that, as a result of dialysis and ultrafiltration, the total body weight and total body water are decreasing in a greater extent in men than in women. By gradually decreasing the body weight, the optimal dry weight could be attained, which resulted in the reduction of blood pressure or even normotension. In the course of dialysis the values of bioimpedance and bioreactance increase. The intradialytic hypotensive indispositions were accompanied by a significant reduction of bioreactance (n = 16). The BMI, total body weight and total body water hyperlipidaemic, hypalbuminic patients with treatment-resistant hypertension are considerably larger than those of the patients with normal blood pressure (p<0.01). During Cardio Tens monitoring 53% of the patients proved to be dippers, 47% of whom had ST depression, while in 73% of the non-dippers ischaemic alterations were encountered together with high hyperbaric impact values. The total body weights and total water compartments of patients returning to dialysis with an excess body weight of more than 3.5 kg were significantly larger than of patients who were cooperative and had no oedemas. In the last hour of dialysis and during the following few hours, arrhythmias and ST depressions of the cardiovascularly instable patients appeared more frequently. The total water compartments of these patients are significantly larger than normotensive, normolipaemic patients with appropriate serum albumin concentrations. The importance of the BIA and Cardio Tens monitoring in determining the optimal dry body weight and improving the cardiovascular condition of the patients is emphasized.
作者对66例接受慢性血液透析治疗的患者(28例男性,38例女性)进行了生物阻抗分析以及Cardio Tens(24小时动态血压监测和心电图)监测。他们研究了透析前、透析期间和透析后的体重、水代谢区间变化和脂肪体重变化之间的相关性,以及记录的血压值和心电图改变。基于这种非侵入性方法的测量结果得出结论,由于透析和超滤,男性的总体重和总体水量下降幅度大于女性。通过逐渐减轻体重,可以达到最佳干体重,从而降低血压甚至实现血压正常。在透析过程中,生物阻抗和生物电抗值会升高。透析期间的低血压倾向伴随着生物电抗的显著降低(n = 16)。患有治疗抵抗性高血压的高脂血症、低白蛋白血症患者的体重指数、总体重和总体水量明显高于血压正常的患者(p<0.01)。在Cardio Tens监测期间,53%的患者被证明是勺型血压者,其中47%有ST段压低,而在73%的非勺型血压者中,出现了缺血性改变以及高压影响值升高。体重超重超过3.5 kg且重新开始透析的患者的总体重和总水代谢区间明显大于配合治疗且无水肿的患者。在透析的最后一小时及随后几个小时,心血管不稳定患者的心律失常和ST段压低出现得更为频繁。这些患者的总水代谢区间明显大于血压正常、血脂正常且血清白蛋白浓度合适的患者。强调了生物阻抗分析和Cardio Tens监测在确定最佳干体重和改善患者心血管状况方面的重要性。