Brown W R, Moody D M, Thore C R, Challa V R
Department of Radiology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
AJNR Am J Neuroradiol. 2000 Jan;21(1):79-82.
We report a case of leukoaraiosis that was studied for apoptosis. In the neuropil, the number of cells that showed DNA fragmentation was 2.5 times as great in the area of leukoaraiosis as in the adjacent white matter (P = .004) and 25 times as great as in the nearby cortex (P < .001). Our findings suggest that apoptosis, predominantly of oligodendrocytes, is involved in the pathogenesis of leukoaraiosis. Within the area of leukoaraiosis, we also found numerous small veins that were partially occluded by severe collagenous thickening of the vessel walls. This collagenosis may have contributed to or resulted from chronic ischemia in that area.
我们报告了一例针对凋亡进行研究的脑白质疏松症病例。在神经纤维网中，显示DNA片段化的细胞数量在脑白质疏松症区域是相邻白质的2.5倍（P = 0.004），是附近皮质的25倍（P < 0.001）。我们的研究结果表明，主要是少突胶质细胞的凋亡参与了脑白质疏松症的发病机制。在脑白质疏松症区域内，我们还发现许多小静脉部分被血管壁严重的胶原增厚所阻塞。这种胶原增生可能是该区域慢性缺血的原因或结果。
