Brown W R, Moody D M, Thore C R, Challa V R
Department of Radiology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.
Ann N Y Acad Sci. 2000 Apr;903:39-45. doi: 10.1111/j.1749-6632.2000.tb06348.x.
A high percentage of patients with Alzheimer's disease (AD) show evidence of white matter degeneration known as leukoaraiosis (LA), which is due to chronic ischemia. We found that the periventricular veins tend to become occluded by multiple layers of collagen in the vessel walls in the elderly. This collagen deposition is particularly excessive in LA lesions. Therefore, it is present in the brains of many AD patients, along with other ischemia-causing cerebrovascular pathology. We found evidence that there is severe loss of oligodendrocytes in LA, due to extensive apoptosis. No evidence of inflammation was found in the LA lesions. In thick celloidin sections of AD brain, we have obtained detailed 3D views of small (early) deposits of amyloid (stained with beta-amyloid antibody) around capillaries (stained with collagen IV antibody).
高比例的阿尔茨海默病（AD）患者表现出白质变性的迹象，即脑白质疏松（LA），这是由慢性缺血引起的。我们发现，老年人脑室周围静脉往往会被血管壁中的多层胶原蛋白堵塞。这种胶原蛋白沉积在LA病变中尤为过量。因此，它与其他导致缺血的脑血管病变一起存在于许多AD患者的大脑中。我们发现有证据表明，由于广泛的细胞凋亡，LA中少突胶质细胞严重缺失。在LA病变中未发现炎症迹象。在AD大脑的厚火棉胶切片中，我们获得了毛细血管（用IV型胶原蛋白抗体染色）周围小（早期）淀粉样蛋白沉积物（用β淀粉样蛋白抗体染色）的详细三维视图。
