van De Wijgert J H, Mason P R, Gwanzura L, Mbizvo M T, Chirenje Z M, Iliff V, Shiboski S, Padian N S
The Population Council, New York, NY 10017, USA.
J Infect Dis. 2000 Feb;181(2):587-94. doi: 10.1086/315227.
One hundred sixty-nine Zimbabwean women were studied to determine whether the use of intravaginal practices (cleaning with the fingers, wiping the vagina, and inserting traditional substances) are associated with disturbances of vaginal flora and acquisition of sexually transmitted diseases (STDs). Subjects were interviewed and received counseling and a pelvic examination at enrollment, 1 month, and 6 months, and vaginal specimens were collected at enrollment and at 6 months. Users were more likely than nonusers to have vaginal flora disturbances but were not more likely to acquire an STD (relative risk [RR], 2.15; P=.188). Certain vaginal flora disturbances were associated with increased STD incidence and HIV prevalence. The absence of lactobacilli from the vaginal flora was associated with being positive for human immunodeficiency virus in baseline (odds ratio [OR], 0.24; P=.001) and 6-month transition multivariate models (OR, 0.39; P=.025). The presence of clue cells at baseline was associated with a higher incidence of STDs (RR, 1. 94; P=.025).
对169名津巴布韦女性进行了研究，以确定采用阴道内操作（用手指清洁、擦拭阴道以及插入传统物质）是否与阴道菌群紊乱和性传播疾病（STD）的感染有关。在入组时、1个月和6个月时对受试者进行访谈、咨询及盆腔检查，并在入组时和6个月时采集阴道标本。使用这些操作的女性比未使用者更易出现阴道菌群紊乱，但感染STD的可能性并未增加（相对危险度[RR]为2.15；P = 0.188）。某些阴道菌群紊乱与STD发病率增加和HIV感染率升高有关。阴道菌群中缺乏乳酸杆菌与基线时人类免疫缺陷病毒呈阳性有关（比值比[OR]为0.24；P = 0.001），在6个月时的多变量模型转变中也有关（OR为0.39；P = 0.025）。基线时出现线索细胞与STD的较高发病率有关（RR为1.94；P = 0.025）。
