Dallabetta G A, Miotti P G, Chiphangwi J D, Liomba G, Canner J K, Saah A J
Department of Epidemiology, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland, USA.
AIDS. 1995 Mar;9(3):293-7.
To assess the prevalence of traditional vaginal agent use in Malawian women and its association with HIV infection.
Consenting, consecutive antenatal women were administered a questionnaire and screened for sexually transmitted diseases (STD) including HIV.
Of the 6603 consenting women, 886 (13%) reported using intravaginal agents for tightening and 2222 (34%) for self-treatment of vaginal discharge and itching. A higher proportion of HIV-infected than uninfected women (17% versus 14%) reported use of intravaginal agents for treatment (odds ratio, 1.29; 95% confidence interval, 1.05-1.57), but no difference in HIV status was found when these agents were used for tightening. In multivariate analysis, vaginal agent use for treatment was independently associated with HIV seropositivity.
The association of HIV infection with vaginal agents for self-treatment, but not for tightening, suggests that STD may play a role or that vaginal agents are used differently for the two purposes. In addition to a small increased risk of HIV infection associated with vaginal agent use, these agents may interfere with condom effectiveness or acceptability of vaginal microbicides.
评估马拉维女性使用传统阴道用药的情况及其与艾滋病毒感染的关联。
对同意参与的连续产前女性进行问卷调查，并对包括艾滋病毒在内的性传播疾病进行筛查。
在6603名同意参与的女性中，886名（13%）报告将阴道内用药用于收紧阴道，2222名（34%）用于自我治疗白带异常和瘙痒。报告阴道内用药进行治疗的艾滋病毒感染女性比例高于未感染女性（17%对14%）（比值比，1.29；95%置信区间，1.05 - 1.57），但在将这些药物用于收紧阴道时，未发现艾滋病毒感染状况存在差异。在多变量分析中，阴道用药进行治疗与艾滋病毒血清阳性独立相关。
艾滋病毒感染与用于自我治疗而非收紧阴道的阴道用药之间的关联表明，性传播疾病可能起了作用，或者这两种用途下阴道用药的使用方式有所不同。除了与使用阴道用药相关的艾滋病毒感染风险略有增加外，这些药物可能会干扰避孕套的有效性或阴道杀菌剂的可接受性。
