Quiroz E S, Bern C, MacArthur J R, Xiao L, Fletcher M, Arrowood M J, Shay D K, Levy M E, Glass R I, Lal A
Epidemic Intelligence Service, Epidemiology Program Office, and Respiratory and Enteric Viruses Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, 30341, USA.
J Infect Dis. 2000 Feb;181(2):695-700. doi: 10.1086/315279.
In September and October 1998, a cryptosporidiosis outbreak occurred on a Washington, DC, university campus. In a case-control study of 88 case patients and 67 control subjects, eating in 1 of 2 cafeterias was associated with diarrheal illness (P<.001). Morbidity was associated with eating dinner on 22 September (odds ratio, 8.1; 95% confidence interval, 3.4-19.5); weaker associations were found for 6 other meals. Cryptosporidium parvum was detected in stool specimens of 16 (70%) of 23 ill students and 2 of 4 ill employees. One ill foodhandler with laboratory-confirmed C. parvum prepared raw produce on 20-22 September. All 25 Cryptosporidium isolates submitted for DNA analysis, including 3 from the ill foodhandler, were genotype 1. This outbreak illustrates the potential for cryptosporidiosis to cause foodborne illness. Epidemiologic and molecular evidence indicate that an ill foodhandler was the likely outbreak source.
1998年9月和10月,华盛顿特区的一所大学校园爆发了隐孢子虫病疫情。在一项针对88例病例患者和67名对照对象的病例对照研究中,在两家自助餐厅中的一家就餐与腹泻病有关(P<0.001)。发病率与9月22日吃晚餐有关(比值比,8.1;95%置信区间,3.4 - 19.5);在其他6餐中发现的关联较弱。在23名患病学生中的16名(70%)和4名患病员工中的2名的粪便标本中检测到微小隐孢子虫。一名实验室确诊感染微小隐孢子虫的患病食品处理人员在9月20日至22日处理过生鲜农产品。提交进行DNA分析的所有25株隐孢子虫分离株,包括3株来自患病食品处理人员的分离株,均为基因型1。此次疫情表明隐孢子虫病有可能导致食源性疾病。流行病学和分子证据表明,一名患病的食品处理人员可能是疫情源头。