Peters L J, Hussey D H, Fletcher G H, Baumann P A, Olson M H
AJR Am J Roentgenol. 1979 Apr;132(4):637-42. doi: 10.2214/ajr.132.4.637.
The records of 248 patients treated with fast neutrons and of 102 comparable but nonrandomized control patients treated conventionally with photons, surgery, or combined surgery and photon irradiation were reviewed. Fast neutron therapy included treatment with neutrons alone, a neutron boost after photon therapy, or a schedule of alternating neutron and photon treatments (mixed beam). The results with mixed beam irradiation were superior to those obtained with the other neutron therapy techniques, and compared favorably with the results of standard treatment methods. However, the lack of a conclusive advantage for neutron therapy in this pilot study illustrates the need for on-going randomized clinical trials.
回顾了248例接受快中子治疗的患者以及102例采用光子、手术或手术联合光子照射等传统方法进行治疗的可比但非随机对照患者的记录。快中子治疗包括单纯中子治疗、光子治疗后的中子增强治疗或中子与光子交替治疗方案（混合束）。混合束照射的结果优于其他中子治疗技术，并与标准治疗方法的结果相比具有优势。然而，在这项初步研究中，中子治疗缺乏确凿的优势，这表明需要进行持续的随机临床试验。
