Wambersie A, Battermann J J
Strahlentherapie. 1985 Dec;161(12):746-55.
Part of the clinical results from the "EORTC Heavy-Particle Therapy Group" are reviewed (September 1984). Fast neutrons can bring a significant benefit, compared to conventional photon (or electron) techniques, in well defined patient series. A benefit for neutrons is observed, in Hammersmith and in Amsterdam, for locally extended salivary gland tumours. Soft tissue sarcomas can also be considered as a good indication for neutron therapy, especially when they are slowly growing and well differentiated, as shown in Essen, Hammersmith and Louvain-la-Neuve. Neutrons can bring an advantage in the treatment of some melanoma patients as shown in Hammersmith. For locally advanced prostatic carcinoma, better results for neutrons are shown in Hamburg and Louvain-la-Neuve. These data are similar to those observed in the United States from the RTOG studies. Due to a reduced differential effect between tissues after neutron treatment, irradiation of large volumes of normal tissues, at high neutron dose, should be avoided. Different possible combinations between neutrons and photons (boost, mixed schedule) are discussed.
回顾了“欧洲癌症研究与治疗组织重粒子治疗小组”的部分临床结果（1984年9月）。与传统光子（或电子）技术相比，在明确界定的患者系列中，快中子可带来显著益处。在哈默史密斯和阿姆斯特丹，对于局部扩展的唾液腺肿瘤，观察到中子治疗的益处。软组织肉瘤也可被视为中子治疗的良好适应症，尤其是当它们生长缓慢且分化良好时，如在埃森、哈默史密斯和鲁汶拉新所见。如哈默史密斯的研究所示，中子在某些黑色素瘤患者的治疗中可带来优势。对于局部晚期前列腺癌，汉堡和鲁汶拉新的研究显示中子治疗效果更佳。这些数据与美国放射肿瘤学组（RTOG）研究中观察到的数据相似。由于中子治疗后组织间的差异效应减小，应避免高剂量中子照射大量正常组织。文中还讨论了中子与光子之间不同的可能组合（增强、混合方案）。
