Takeda A, Shimada H, Imaseki H, Okazumi S, Natsume T, Suzuki T, Ochiai T
Second Department of Surgery, School of Medicine, Chiba University, Chuou-ku, Chiba-city 260-8670, Japan.
Oncol Rep. 2000 Mar-Apr;7(2):333-8.
Vascular endothelial growth factor (VEGF) is known as a potent inducer of angiogenesis in various human cancers. Serum VEGF concentrations of colorectal cancer patients was assessed for their clinical significance as a tumor marker. Serum samples were obtained at admission from 24 healthy volunteers and 111 patients with colorectal cancer. Preoperative serum VEGF concentrations, which are significantly higher than those of healthy controls, reflect clinical stage progression, depth of invasion, liver metastasis, lymph node metastasis and lymphatic invasion. Consequently, detection of VEGF could serve as a clinically useful marker for colorectal cancer progression and metastasis independent of other markers.
血管内皮生长因子（VEGF）是多种人类癌症中一种有效的血管生成诱导剂。评估了结直肠癌患者血清VEGF浓度作为肿瘤标志物的临床意义。在入院时从24名健康志愿者和111名结直肠癌患者中获取血清样本。术前血清VEGF浓度显著高于健康对照组，反映了临床分期进展、浸润深度、肝转移、淋巴结转移和淋巴管浸润情况。因此，检测VEGF可作为一种独立于其他标志物的、对结直肠癌进展和转移具有临床实用价值的标志物。
