Broll R, Erdmann H, Windhövel U, Duchrow M, Strik M W
Klinik für Chirurgie, Medizinische Universität zu Lübeck, Ratzeburger Allee 160, D-23538 Lübeck.
Langenbecks Arch Chir Suppl Kongressbd. 1998;115(Suppl I):315-8.
The aim of our study was to determine the serum concentration of VEGF in 53 patients with a colorectal carcinoma and 22 healthy volunteers (control group) and to compare it with tumor stage and volume. We found significantly higher serum levels in tumor patients in contrast to the control group and between patients with and without distant metastases. There was also a correlation between high serum concentrations and great tumor volumes, but only weak with tumor stage. Our results support the hypothesis that tumor growth is dependent on angiogenesis and that VEGF is a potent growth factor with angiogenic activity.
我们研究的目的是测定53例结直肠癌患者和22名健康志愿者（对照组）的血清血管内皮生长因子（VEGF）浓度，并将其与肿瘤分期和体积进行比较。我们发现，与对照组相比，肿瘤患者的血清水平显著更高，有远处转移和无远处转移的患者之间也是如此。血清高浓度与大肿瘤体积之间也存在相关性，但与肿瘤分期的相关性较弱。我们的结果支持以下假设：肿瘤生长依赖于血管生成，且VEGF是一种具有血管生成活性的强效生长因子。
