Nakamura Toru, Schwander Stephan K, Donnelly Robert, Ortega Felix, Togo Fumiharu, Broderick Gordon, Yamamoto Yoshiharu, Cherniack Neil S, Rapoport David, Natelson Benjamin H
Pain & Fatigue Study Center, UMDNJ--New Jersey Medical School, Newark, New Jersey 07103, USA.
Clin Vaccine Immunol. 2010 Apr;17(4):582-7. doi: 10.1128/CVI.00379-09. Epub 2010 Feb 24.
The symptoms of chronic fatigue syndrome (CFS) are consistent with cytokine dysregulation. This has led to the hypothesis of immune dysregulation as the cause of this illness. To further test this hypothesis, we did repeated blood sampling for cytokines while patients and matched healthy controls slept in the sleep lab. Because no one method for assaying cytokines is acknowledged to be better than another, we assayed for protein in serum, message in peripheral blood lymphocytes (PBLs), and function in resting and stimulated PBLs. We found no evidence of proinflammatory cytokine upregulation. Instead, in line with some of our earlier studies, we did find some evidence to support a role for an increase in interleukin-10, an anti-inflammatory cytokine. Although the changes were small, they may contribute to the common complaint in CFS patients of disrupted sleep.
慢性疲劳综合征（CFS）的症状与细胞因子失调相符。这引发了免疫失调是该疾病病因的假说。为了进一步验证这一假说，我们在患者和匹配的健康对照者在睡眠实验室睡觉时，对细胞因子进行了多次血液采样。由于没有一种公认的检测细胞因子的方法优于其他方法，我们检测了血清中的蛋白质、外周血淋巴细胞（PBL）中的信使以及静息和刺激后的PBL中的功能。我们没有发现促炎细胞因子上调的证据。相反，与我们早期的一些研究一致，我们确实发现了一些证据支持抗炎细胞因子白细胞介素-10增加所起的作用。尽管变化很小，但它们可能导致CFS患者睡眠中断这一常见主诉。
