Yeramian E, Buc H
Unité de physico-chimie des macromolécules biologiques, (URA 1773 du CNRS), Institut Pasteur, Paris, France.
Res Microbiol. 1999 Nov-Dec;150(9-10):745-54. doi: 10.1016/s0923-2508(99)00118-7.
A series of complete bacterial genome sequences have recently become available and powerful methods have been developed for the identification of tandem repeats on a very large scale. It is thus possible to derive extensive comparative descriptions of such repeats at the level of complete genomes, as illustrated here for three different bacterial genomes: Escherichia coli, Haemophilus influenzae, and Mycobacterium tuberculosis. Such sequence analyses can be usefully complemented by structural characterisations of the repeats.
最近已获得一系列完整的细菌基因组序列,并且已经开发出强大的方法来大规模鉴定串联重复序列。因此,有可能在完整基因组水平上获得此类重复序列的广泛比较描述,此处以三种不同的细菌基因组为例进行说明:大肠杆菌、流感嗜血杆菌和结核分枝杆菌。此类序列分析可以通过重复序列的结构表征得到有效补充。