哮喘患者中一氧化氮合酶1、一氧化氮合酶2和一氧化氮合酶3基因的变体
Variants of NOS1, NOS2, and NOS3 genes in asthmatics.
作者信息
Gao P S, Kawada H, Kasamatsu T, Mao X Q, Roberts M H, Miyamoto Y, Yoshimura M, Saitoh Y, Yasue H, Nakao K, Adra C N, Kun J F, Moro-oka S, Inoko H, Ho L P, Shirakawa T, Hopkin J M
机构信息
Experimental Medicine Unit, University of Wales Swansea, Swansea, United Kingdom.
出版信息
Biochem Biophys Res Commun. 2000 Jan 27;267(3):761-3. doi: 10.1006/bbrc.1999.2030.
Nitric oxide (NO) gas concentrations are higher in expired air in asthmatics. NO is synthesized by three isoforms of NO synthase (NOS) encoded by three distinct genes, NOS1, NOS2, and NOS3. Genome-wide searches have identified linkages to asthma on chromosomes 7, 12, and 17 where these three genes are localized. No association study, however, has been reported to date. To test whether variants of NOS1, NOS2, and NOS3 relate to asthma, a genetic association study was conducted in a British population (n = 300). Intragenic microsatellite variants of NOS1 were significantly associated with asthma [odds ratio (OR) = 2.08, 95% CI: 1.20-3.57 (95% CI), P = 0.008 (Pc = 0.048)], but not with IgE levels. Neither NOS2 nor NOS3 variants showed any association with asthma nor IgE levels. These findings suggest that NOS1 variants may be a significant contributor to asthma in a British population.
哮喘患者呼出气体中的一氧化氮（NO）气体浓度较高。NO由三个不同基因NOS1、NOS2和NOS3编码的三种一氧化氮合酶（NOS）同工型合成。全基因组搜索已确定在7号、12号和17号染色体上存在与哮喘的连锁关系，而这三个基因就位于这些染色体上。然而，迄今为止尚未有相关关联研究的报道。为了测试NOS1、NOS2和NOS3的变异体是否与哮喘有关，在一个英国人群（n = 300）中进行了一项基因关联研究。NOS1的基因内微卫星变异体与哮喘显著相关[比值比（OR）= 2.08，95%置信区间：1.20 - 3.57（95%CI），P = 0.008（Pc = 0.048）]，但与IgE水平无关。NOS2和NOS3的变异体均未显示与哮喘或IgE水平有任何关联。这些发现表明，在英国人群中，NOS1变异体可能是导致哮喘的一个重要因素。
Zotero 插件