Varanasi S S, Athanasou N A, Briceno I, Papiha S S, Datta H K
Department of Clinical Biochemistry, Medical School, University of Newcastle, Newcastle upon Tyne, UK.
J Clin Pathol. 1999 Oct;52(10):782-4. doi: 10.1136/jcp.52.10.782.
To examine the possible influence of the MHC class II antigens alleles in the formation of the multinucleate aggressive giant cell tumour of bone.
HLA class II antigen alleles were investigated in eight white patients from north east England with confirmed diagnosis of giant cell tumour of bone. All had locally aggressive, immunophenotypically HLA-DR negative giant cell tumours.
Five of the eight patients were found to be positive for HLA-DRB10801/3, the distribution of this allele in healthy white controls being quite low (2%). All but one of the patients possessing DRB1080 also expressed DRB1*070.
HLA-DRB1*080 is pre-dominant in patients with immunophenotypic HLA-DR negative giant cell tumour of bone; individuals with the genotype 070/080 are at particularly high risk of developing giant cell tumour of bone.
研究MHCⅡ类抗原等位基因在骨侵袭性多核巨细胞瘤形成过程中可能产生的影响。
对8名来自英格兰东北部、确诊为骨巨细胞瘤的白人患者的HLAⅡ类抗原等位基因进行了研究。所有患者均患有局部侵袭性、免疫表型为HLA - DR阴性的巨细胞瘤。
8名患者中有5名被发现HLA - DRB10801/3呈阳性，该等位基因在健康白人对照组中的分布相当低（2%）。除1名患者外，所有携带DRB1080的患者也表达DRB1*070。
HLA - DRB1*080在免疫表型为HLA - DR阴性的骨巨细胞瘤患者中占主导地位；基因型为070/080的个体患骨巨细胞瘤的风险特别高。
