Chen Peng, Ma Qiu-Gang, Ji Cheng, Zhang Jian-Yun, Zhao Li-Hong, Zhang Yong, Jie Yong-Ze
State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Int J Mol Sci. 2011;12(12):8476-88. doi: 10.3390/ijms12128476. Epub 2011 Nov 29.
The effects of lipoic acid (LA) on the antioxidant status of broilers were investigated. Birds (1 day old) were randomly assigned to four groups and fed corn-soybean diets supplemented with 0, 100, 200, 300 mg/kg LA, respectively. The feeding program included a starter diet from 1 to 21 days of age and a grower diet from 22 to 42 days of age. Serum, liver and muscle samples were collected at 42 days of age. For antioxidant enzymes, superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activity in serum, liver and breast muscle significantly increased in chickens fed with LA. The concentration of malondiadehyde (MDA), an indicator of lipid peroxidation, was significantly lower in serum, liver and leg muscle in birds that received LA than in the control group. Treatments with LA significantly increased glutathione (GSH) content in liver and increased α-tocopherol content in leg muscle as compared to the control. These results indicate that dietary supplementation with 300 mg/kg LA may enhance antioxidant capability and depress oxidative stress in broilers.
研究了硫辛酸（LA）对肉鸡抗氧化状态的影响。将1日龄雏鸡随机分为四组，分别饲喂添加0、100、200、300mg/kg LA的玉米-大豆日粮。饲养程序包括1至21日龄的雏鸡日粮和22至42日龄的生长鸡日粮。在42日龄时采集血清、肝脏和肌肉样本。对于抗氧化酶，饲喂LA的鸡血清、肝脏和胸肌中的超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GSH-Px）活性显著增加。脂质过氧化指标丙二醛（MDA）的浓度在接受LA的鸡的血清、肝脏和腿部肌肉中显著低于对照组。与对照组相比，LA处理显著增加了肝脏中的谷胱甘肽（GSH）含量，并增加了腿部肌肉中的α-生育酚含量。这些结果表明，日粮中添加300mg/kg LA可能会增强肉鸡的抗氧化能力并降低氧化应激。
