Sumathi R, Jayanthi S, Kalpanadevi V, Varalakshmi P
Department of Medical Biochemistry, Dr. A. L. Mudaliar Post Graduate Institute of Basic Medical Sciences, Taramani, University of Madras, India.
Pharmacol Res. 1993 May-Jun;27(4):309-18. doi: 10.1006/phrs.1993.1031.
The cytoprotective activity of alpha-lipoic acid against free radical toxicity, manifested during experimental hyperoxaluria, has been investigated. Glycollate was used as the inducer of oxalate hyperoxaluria in rats. The increase in lipid peroxidation and superoxide dismutase (SOD) activity, associated with a decrease in catalase activity and glutathione (GSH) level, are the salient features observed in tissues of hyperoxaluric rats. Free radical toxicity in the glycollate fed rats is effectively counteracted by lipoic acid administration. Lipoic acid administration brought about a significant decrease in peroxidative levels with an increase in catalase activity and glutathione level. These observations highlight the antioxidant property of alpha-lipoic acid and its cytoprotective action against experimental hyperoxaluria.
已经研究了α-硫辛酸在实验性高草酸尿症期间表现出的对自由基毒性的细胞保护活性。乙醇酸盐被用作大鼠草酸高草酸尿症的诱导剂。脂质过氧化和超氧化物歧化酶（SOD）活性增加，同时过氧化氢酶活性和谷胱甘肽（GSH）水平降低，是高草酸尿症大鼠组织中观察到的显著特征。给喂食乙醇酸盐的大鼠施用硫辛酸可有效对抗自由基毒性。施用硫辛酸使过氧化水平显著降低，同时过氧化氢酶活性和谷胱甘肽水平增加。这些观察结果突出了α-硫辛酸的抗氧化特性及其对实验性高草酸尿症的细胞保护作用。
