蛋白质降解速率与根据氨基酸组成和亚基大小计算出的一个参数之间的相关性。
Correlation of degradative rates of proteins with a parameter calculated from amino acid composition and subunit size.
作者信息
Momany F A, Aguanno J J, Larrabee A R
出版信息
Proc Natl Acad Sci U S A. 1976 Sep;73(9):3093-7. doi: 10.1073/pnas.73.9.3093.
Abstract
A parameter is developed which relates the amino acid composition and subunit size of a protein to the degradative rate in vivo. This parameter was calculated for 11 rat liver proteins and a plot versus the half-lives of these proteins is linear and has a coefficient of correlation of -0.96. Evidence is presented which suggests that the density of excess acidic amino acids on the surface of the protein is the most important factor in determining differential turnover.
摘要
开发了一个参数，该参数将蛋白质的氨基酸组成和亚基大小与体内降解速率联系起来。针对11种大鼠肝脏蛋白质计算了该参数，并且将其与这些蛋白质的半衰期作图，得到的是一条直线，相关系数为-0.96。所提供的证据表明，蛋白质表面过量酸性氨基酸的密度是决定差异周转率的最重要因素。
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Correlation of degradative rates of proteins with a parameter calculated from amino acid composition and subunit size.蛋白质降解速率与根据氨基酸组成和亚基大小计算出的一个参数之间的相关性。
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