Hoffman A, Stepensky D
Department of Pharmaceutics, School of Pharmacy, Faculty of Medicine, Hebrew University of Jerusalem, Israel.
Crit Rev Ther Drug Carrier Syst. 1999;16(6):571-639.
Because of various pharmacodynamic properties, such as the nonlinearity of the concentration-effect relationship, activation of feedback homeostatic mechanisms, induction of pharmacodynamic tolerance, etc., administration of the same dose of drug by different modes is expected to produce different outcomes. This review clarifies the theoretical and practical aspects of the impact of different modes of drug administration on the magnitude of response, and hence on therapy outcomes. It discusses how the interrelationship between the pharmacodynamic properties and the drug input function affects the magnitude of response. To demonstrate this special dimension of drug therapy, relevant pharmacodynamic data was obtained for drugs with different therapeutic applications, including antibiotics, analgesics, diuretics, anti-cancer, anti-ulcer, anti-inflammatory, anti-hypertensive, lipid-lowering anti-parkinsonian, and immunosuppressive drugs. These examples provide guidelines for implementing the role of the mode of drug administration (including rate, schedule, and route of drug treatment) during drug development or optimization of drug therapy.
由于各种药效学特性，如浓度-效应关系的非线性、反馈稳态机制的激活、药效学耐受性的诱导等，不同给药方式给予相同剂量的药物预计会产生不同的结果。本综述阐明了不同给药方式对反应程度以及治疗结果影响的理论和实践方面。它讨论了药效学特性与药物输入函数之间的相互关系如何影响反应程度。为了说明药物治疗的这一特殊维度，获取了具有不同治疗应用的药物的相关药效学数据，包括抗生素、镇痛药、利尿剂、抗癌药、抗溃疡药、抗炎药、抗高血压药、降脂药、抗帕金森病药和免疫抑制药。这些例子为在药物开发或优化药物治疗过程中发挥给药方式（包括给药速率、给药方案和给药途径）的作用提供了指导。
