Deutsch T, Sali A
Computer Centre, Semmelweis University of Medicine, Budapest, Hungary.
Acta Physiol Hung. 1993;81(1):3-11.
An optimal drug input may be defined as producing an ideal therapeutic effect as closely as possible without exceeding predetermined safety limits on any adverse drug effects. The intensity and time patterns of the drug-elicited response are functions of the pharmacodynamic properties of the drug in the patient. Drug input optimisation can be considered as a control problem and the different control engineering techniques may serve to assist in planning/implementing drug dosage regimens. This paper reviews some problems associated with planning optimal drug therapy in different clinical context and illustrates the solution of such problems by clinical examples.
最佳药物输入可定义为在不超过任何药物不良反应的预定安全限度的情况下，尽可能产生理想的治疗效果。药物引发反应的强度和时间模式是药物在患者体内药效学特性的函数。药物输入优化可被视为一个控制问题，不同的控制工程技术可用于协助规划/实施给药方案。本文综述了在不同临床背景下规划最佳药物治疗相关的一些问题，并通过临床实例说明了此类问题的解决方案。
