Goode B L, Drubin D G, Barnes G
Molecular and Cell Biology Department, University of California Berkeley, Oxford and Hearst, CA 94720-3202, USA. goode@uclink4. berkeley.edu
Curr Opin Cell Biol. 2000 Feb;12(1):63-71. doi: 10.1016/s0955-0674(99)00058-7.
In diverse cell types, microtubule (MT) and actin filament networks cooperate functionally during a wide variety of processes, including vesicle and organelle transport, cleavage furrow placement, directed cell migration, spindle rotation, and nuclear migration. The mechanisms by which MTs and actin filaments cooperate to mediate these different processes can be grouped into two broad categories: coordinated MT- and actin-based transport to move vesicles, organelles, and cell fate determinants; and targeting and capture of MT ends at cortical actin sites. Over the past several years, a growing number of cellular factors that bridge these cytoskeletal systems have been identified. These include 'hetero-motor' complexes (physically associated myosin and kinesin), myosin-CLIP170 complexes, formin homology (FH) proteins, dynein and the dynactin complex, Kar9p, coronin, Kelch repeat-containing proteins, and ERM proteins.
在多种细胞类型中，微管（MT）和肌动蛋白丝网络在各种各样的过程中发挥功能协同作用，这些过程包括囊泡和细胞器运输、分裂沟定位、定向细胞迁移、纺锤体旋转以及核迁移。微管和肌动蛋白丝协同介导这些不同过程的机制可大致分为两大类：基于微管和肌动蛋白的协同运输，以移动囊泡、细胞器和细胞命运决定因子；以及微管末端在皮质肌动蛋白位点的靶向和捕获。在过去几年中，已经鉴定出越来越多连接这些细胞骨架系统的细胞因子。这些因子包括“异源运动”复合体（物理上相关的肌球蛋白和驱动蛋白）、肌球蛋白-CLIP170复合体、formin同源（FH）蛋白、动力蛋白和动力蛋白激活复合体、Kar9p、冠蛋白、含kelch重复序列的蛋白以及ERM蛋白。
