Burke D J
Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia 22906, USA.
Curr Opin Genet Dev. 2000 Feb;10(1):26-31. doi: 10.1016/s0959-437x(99)00040-4.
Cell viability requires accurate chromosome segregation at mitosis. The spindle checkpoint ensures that anaphase is not attempted until the sister chromatids of each chromosome are attached to spindle microtubules from opposite poles. The checkpoint mechanism involves a signal transduction cascade that is more complex than was originally envisioned.
细胞的生存能力需要在有丝分裂时准确地进行染色体分离。纺锤体检查点可确保在每条染色体的姐妹染色单体与来自相对两极的纺锤体微管相连之前，不会尝试进入后期。检查点机制涉及一个比最初设想更为复杂的信号转导级联反应。
