Brose K, Tessier-Lavigne M
Departments of Biochemistry and Biophysics, University of California, San Francisco, CA 94143-0452, USA.
Curr Opin Neurobiol. 2000 Feb;10(1):95-102. doi: 10.1016/s0959-4388(99)00066-5.
In the past year, Slit proteins have been identified as important regulators of axon guidance and cell migration in Drosophila and vertebrates. Remarkably, they were simultaneously identified as negative regulators, repelling various axonal and cell migrations in both invertebrates and vertebrates, and as positive regulators, stimulating branching and extension of at least one class of axons in vertebrates.
在过去的一年里，Slit蛋白已被确定为果蝇和脊椎动物中轴突导向和细胞迁移的重要调节因子。值得注意的是，它们同时被确定为负调节因子，在无脊椎动物和脊椎动物中排斥各种轴突和细胞迁移，以及正调节因子，刺激脊椎动物中至少一类轴突的分支和延伸。
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