SCH56592在兔侵袭性曲霉病模型中的疗效。
Efficacy of SCH56592 in a rabbit model of invasive aspergillosis.
作者信息
Kirkpatrick W R, McAtee R K, Fothergill A W, Loebenberg D, Rinaldi M G, Patterson T F
机构信息
Departments of Medicine, San Antonio, Texas 78284, USA.
出版信息
Antimicrob Agents Chemother. 2000 Mar;44(3):780-2. doi: 10.1128/AAC.44.3.780-782.2000.
Abstract
SCH56592 (SCH) was evaluated in an immunosuppressed rabbit model of invasive aspergillosis. SCH was more effective than similar doses of itraconazole and as effective as amphotericin B in the clearance of Aspergillus spp. from tissues. Compared with controls, SCH regimens reduced mortality, improved survival, and significantly reduced tissue colony counts.
摘要
在免疫抑制的侵袭性曲霉病兔模型中对SCH56592（SCH）进行了评估。在从组织中清除曲霉菌属方面，SCH比相似剂量的伊曲康唑更有效，且与两性霉素B效果相当。与对照组相比，SCH治疗方案降低了死亡率，提高了生存率，并显著减少了组织菌落计数。
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