SCH56592对小鼠侵袭性曲霉病的治疗
SCH56592 treatment of murine invasive aspergillosis.
作者信息
Graybill J R, Bocanegra R, Najvar L K, Luther M F, Loebenberg D
机构信息
The University of Texas Health Science Center at San Antonio, 78284, USA.
出版信息
J Antimicrob Chemother. 1998 Oct;42(4):539-42. doi: 10.1093/jac/42.4.539.
Mice were immunosuppressed using corticosteroids and infected with conidia of Aspergillus fumigatus. Beginning 1 day after infection, mice were treated orally either with Noble agar or with SCH56592 suspended in Noble agar, or intraperitoneally with amphotericin B. SCH56592 prolonged survival and reduced lung tissue counts of A. fumigatus, while amphotericin B had marginal benefit. SCH56592 merits further development for treatment of aspergillosis.
使用皮质类固醇对小鼠进行免疫抑制，然后用烟曲霉分生孢子感染它们。从感染后第1天开始，给小鼠口服诺布尔琼脂或悬浮于诺布尔琼脂中的SCH56592，或者腹腔注射两性霉素B。SCH56592延长了生存期并减少了肺组织中的烟曲霉数量，而两性霉素B的益处不大。SCH56592在治疗曲霉病方面值得进一步研发。
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