特比萘芬与两性霉素B联合治疗兔实验性侵袭性曲霉病模型的研究
Combination therapy with terbinafine and amphotericin B in a rabbit model of experimental invasive aspergillosis.
作者信息
Kirkpatrick William R, Vallor Ana C, McAtee Robert K, Ryder Neil S, Fothergill Annette W, Rinaldi Michael G, Patterson Thomas F
机构信息
Department of Medicine, Division of Infectious Diseases, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, Mail Code 7881, San Antonio, Texas 78229-3900, USA.
出版信息
Antimicrob Agents Chemother. 2005 Nov;49(11):4751-3. doi: 10.1128/AAC.49.11.4751-4753.2005.
Abstract
Antagonistic effects of combination therapy using amphotericin B (AmB) with agents which block ergosterol synthesis are a concern. Terbinafine was evaluated with AmB to assess antagonism or synergy in a rabbit model of invasive aspergillosis. Terbinafine had relatively little activity but did not demonstrate antagonism against AmB in our model.
摘要
两性霉素B（AmB）与阻断麦角固醇合成的药物联合治疗的拮抗作用令人担忧。在侵袭性曲霉病的兔模型中，对特比萘芬与AmB联合使用进行评估，以判断其是拮抗还是协同作用。特比萘芬活性相对较低，但在我们的模型中未显示出对AmB的拮抗作用。
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