茚地那韦浓度与圣约翰草
Indinavir concentrations and St John's wort.
作者信息
Piscitelli S C, Burstein A H, Chaitt D, Alfaro R M, Falloon J
出版信息
Lancet. 2000 Feb 12;355(9203):547-8. doi: 10.1016/S0140-6736(99)05712-8.
Abstract
St John's wort reduced the area under the curve of the HIV-1 protease inhibitor indinavir by a mean of 57% (SD 19) and decreased the extrapolated 8-h indinavir trough by 81% (16) in healthy volunteers. A reduction in indinavir exposure of this magnitude could lead to the development of drug resistance and treatment failure.
摘要
在健康志愿者中，圣约翰草使HIV-1蛋白酶抑制剂茚地那韦的曲线下面积平均降低了57%（标准差19），并使推算的8小时茚地那韦谷浓度降低了81%（16）。茚地那韦暴露量如此大幅度的降低可能导致耐药性的产生和治疗失败。
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