Collagen gel in osseous defects. A preliminary study.

In a preliminary study, the effects of a biodegradable collagen gel on the healing of osseous defects were examined. Histologic and biochemical observations made on the seventh day after placement revealed that the collagen gel is well tolerated by the recipient and might be an effective stimulator of the formation of reparative bone. However, between the seventh and fourteenth days after placement, the deposition of reparative osseous tissues at the site of implant was significantly retarded. The possible implication of these findings is discussed.