Riviere G R, Derkowski J L
Oral Surg Oral Med Oral Pathol. 1976 Nov;42(5):582-7. doi: 10.1016/0030-4220(76)90208-5.
Teeth transplanted between inbred lines of mice that differ by strong histocompatibility barriers are promptly rejected. However, when only one weak antigen difference exists between donor and recipient, teeth are known tp survive indefinitely. The purpose of this study was to determine if the histocompatibility barrier could be increased to two weak antigens without inducing a rejection episode. Allografted teeth was examined from 30 to 210 days after transplantation and, contrary to expectations, the teeth were rejected at about 60 days. Thus, all but the weakest of histocompatibility barriers are sufficient to cause the rejection of tooth allotransplants in mice.
在具有强大组织相容性屏障差异的近交系小鼠之间移植的牙齿会迅速被排斥。然而，当供体和受体之间仅存在一个弱抗原差异时，牙齿能够无限期存活。本研究的目的是确定组织相容性屏障是否可以增加到两个弱抗原而不引发排斥反应。对移植后30至210天的同种异体移植牙齿进行检查，与预期相反，牙齿在大约60天时被排斥。因此，除了最弱的组织相容性屏障外，其他所有屏障都足以导致小鼠牙齿同种异体移植被排斥。
