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Productive replication of human adenoviruses in mouse epidermal cells.人类腺病毒在小鼠表皮细胞中的有效复制。
J Virol. 2000 Mar;74(6):2895-9. doi: 10.1128/jvi.74.6.2895-2899.2000.
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New oncolytic adenoviruses with hypoxia- and estrogen receptor-regulated replication.具有缺氧和雌激素受体调节复制功能的新型溶瘤腺病毒。
Hum Gene Ther. 2002 Sep 20;13(14):1737-50. doi: 10.1089/104303402760293574.
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Genetically modified adenoviruses against gliomas: from bench to bedside.抗胶质瘤的基因工程腺病毒：从实验台到临床应用
Neurology. 2004 Aug 10;63(3):418-26. doi: 10.1212/01.wnl.0000133302.15022.7f.
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Mutant adenoviruses selectively replication-competent in tumor cells.在肿瘤细胞中具有选择性复制能力的突变腺病毒。
Adv Exp Med Biol. 2000;465:65-71. doi: 10.1007/0-306-46817-4_7.
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A new type of adenovirus vector that utilizes homologous recombination to achieve tumor-specific replication.一种利用同源重组实现肿瘤特异性复制的新型腺病毒载体。
J Virol. 2002 Nov;76(21):10994-1002. doi: 10.1128/jvi.76.21.10994-11002.2002.
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Expression of p53 synergistically augments caspases-mediated apoptosis induced by replication-competent adenoviruses in pancreatic carcinoma cells.p53的表达协同增强了复制能力强的腺病毒在胰腺癌细胞中诱导的半胱天冬酶介导的细胞凋亡。
Cancer Gene Ther. 2015 Sep;22(9):445-53. doi: 10.1038/cgt.2015.33. Epub 2015 Aug 7.
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Insufficient accumulation of viral late mRNAs restricts the replicative cycle of human adenovirus type 37 in A549 cells.病毒晚期mRNA积累不足限制了37型人腺病毒在A549细胞中的复制周期。
Arch Virol. 2009;154(9):1401-7. doi: 10.1007/s00705-009-0451-4. Epub 2009 Jul 16.
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An oncolytic adenovirus selective for retinoblastoma tumor suppressor protein pathway-defective tumors: dependence on E1A, the E2F-1 promoter, and viral replication for selectivity and efficacy.一种对视网膜母细胞瘤肿瘤抑制蛋白通路缺陷型肿瘤具有选择性的溶瘤腺病毒：对E1A、E2F-1启动子以及病毒复制的依赖性，以实现选择性和有效性。
Cancer Res. 2003 Apr 1;63(7):1490-9.
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Adenovirus E1A targets the DREF nuclear factor to regulate virus gene expression, DNA replication, and growth.腺病毒E1A靶向DREF核因子以调控病毒基因表达、DNA复制和生长。
J Virol. 2014 Nov;88(22):13469-81. doi: 10.1128/JVI.02538-14. Epub 2014 Sep 10.
引用本文的文献
1
Enhanced potency of immune checkpoint inhibitors against poorly immunological solid tumors by immune stimulatory oncolytic adenoviruses-mediated remodeling of the tumor microenvironment.免疫刺激溶瘤腺病毒介导的肿瘤微环境重塑增强免疫检查点抑制剂对免疫原性差的实体瘤的效力
Mol Med. 2025 May 7;31(1):175. doi: 10.1186/s10020-025-01223-4.
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Mathematical modelling of reoviruses in cancer cell cultures.呼肠孤病毒在癌细胞培养中的数学建模。
PLoS One. 2025 Apr 28;20(4):e0318078. doi: 10.1371/journal.pone.0318078. eCollection 2025.
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Generalization of neoantigen-based tumor vaccine by delivering peptide-MHC complex via oncolytic virus.通过溶瘤病毒递送肽-主要组织相容性复合体实现基于新抗原的肿瘤疫苗的广泛应用。
EMBO Mol Med. 2025 May;17(5):1118-1152. doi: 10.1038/s44321-025-00225-3. Epub 2025 Apr 7.
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Human Adenovirus Entry and Early Events during Infection of Primary Murine Neurons: Immunofluorescence Studies In Vitro.人腺病毒感染原代小鼠神经元过程中的进入及早期事件：体外免疫荧光研究
Pathogens. 2024 Feb 9;13(2):158. doi: 10.3390/pathogens13020158.
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Oncolytic virotherapy in cancer treatment: challenges and optimization prospects.肿瘤溶瘤病毒治疗癌症：挑战与优化前景。
Front Immunol. 2023 Dec 15;14:1308890. doi: 10.3389/fimmu.2023.1308890. eCollection 2023.
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Agent-Based and Continuum Models for Spatial Dynamics of Infection by Oncolytic Viruses.基于主体和连续统模型的溶瘤病毒感染的空间动力学。
Bull Math Biol. 2023 Aug 31;85(10):92. doi: 10.1007/s11538-023-01192-x.
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An Oncolytic Adenovirus Encoding SA-4-1BBL Adjuvant Fused to HPV-16 E7 Antigen Produces a Specific Antitumor Effect in a Cancer Mouse Model.一种编码与HPV-16 E7抗原融合的SA-4-1BBL佐剂的溶瘤腺病毒在癌症小鼠模型中产生特异性抗肿瘤作用。
Vaccines (Basel). 2021 Feb 12;9(2):149. doi: 10.3390/vaccines9020149.
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Microbubble-mediated delivery of human adenoviruses does not elicit innate and adaptive immunity response in an immunocompetent mouse model of prostate cancer.微泡介导的人腺病毒传递在前列腺癌免疫功能正常的小鼠模型中不会引起固有和适应性免疫反应。
J Transl Med. 2019 Jan 11;17(1):19. doi: 10.1186/s12967-019-1771-0.
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Expression of human CD46 and trans-complementation by murine adenovirus 1 fails to allow productive infection by a group B oncolytic adenovirus in murine cancer cells.人 CD46 的表达和鼠腺病毒 1 的转互补作用不能使 B 组溶瘤腺病毒在鼠癌细胞中进行有效的感染。
J Immunother Cancer. 2018 Jun 13;6(1):55. doi: 10.1186/s40425-018-0350-x.
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Fighting Cancer with Mathematics and Viruses.用数学和病毒对抗癌症
Viruses. 2017 Aug 23;9(9):239. doi: 10.3390/v9090239.
本文引用的文献
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Manipulation of adenovirus vectors.腺病毒载体的操控
Methods Mol Biol. 1991;7:109-28. doi: 10.1385/0-89603-178-0:109.
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[Gene therapy of a model of glioblastoma in rats using adenovirus vector encoding the HSVtk gene].[使用编码单纯疱疹病毒胸苷激酶（HSVtk）基因的腺病毒载体对大鼠胶质母细胞瘤模型进行基因治疗]
Bull Cancer. 1997 Nov;84(11):1047-52.
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Gene therapy of experimental malignant mesothelioma using adenovirus vectors encoding the HSVtk gene.使用编码单纯疱疹病毒胸苷激酶（HSVtk）基因的腺病毒载体对实验性恶性间皮瘤进行基因治疗。
Gene Ther. 1997 Apr;4(4):280-7. doi: 10.1038/sj.gt.3300385.
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ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents.ONYX-015是一种E1B基因减毒腺病毒，可引起肿瘤特异性细胞溶解和抗肿瘤疗效，标准化疗药物可增强这种疗效。
Nat Med. 1997 Jun;3(6):639-45. doi: 10.1038/nm0697-639.
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Molecular therapy with recombinant p53 adenovirus in an androgen-independent, metastatic human prostate cancer model.重组p53腺病毒在雄激素非依赖性转移性人前列腺癌模型中的分子治疗
Hum Gene Ther. 1996 Sep 10;7(14):1683-91. doi: 10.1089/hum.1996.7.14-1683.
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An adenovirus mutant that replicates selectively in p53-deficient human tumor cells.一种在p53基因缺失的人类肿瘤细胞中选择性复制的腺病毒突变体。
Science. 1996 Oct 18;274(5286):373-6. doi: 10.1126/science.274.5286.373.
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The ups and downs of adenovirus vectors.腺病毒载体的兴衰
Bull N Y Acad Med. 1996 Summer;73(1):53-8.
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Adenoviruses as gene-delivery vehicles.腺病毒作为基因传递载体。
N Engl J Med. 1996 May 2;334(18):1185-7. doi: 10.1056/NEJM199605023341809.
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Prolonged and effective blockade of tumor necrosis factor activity through adenovirus-mediated gene transfer.通过腺病毒介导的基因转移对肿瘤坏死因子活性进行长期有效的阻断。
Proc Natl Acad Sci U S A. 1994 Jan 4;91(1):215-9. doi: 10.1073/pnas.91.1.215.
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