Arregui C O, Balsamo J, Lilien J
Department of Biological Sciences, Wayne State University, Detroit, Michigan 48202, USA.
Neurochem Res. 2000 Jan;25(1):95-105. doi: 10.1023/a:1007595617447.
During neuronal development, cells respond to a variety of environmental cues through cell surface receptors that are coupled to a signaling transduction machinery based on protein tyrosine phosphorylation and dephosphorylation. Receptor and non-receptor tyrosine kinases have received a great deal of attention; however, in the last few years, receptor (plasma membrane associated) and non-receptor protein-tyrosine phosphatases (PTPs) have also been shown to play important roles in development of the nervous system. In many cases PTPs have provocative distribution patterns or have been shown to be associated with specific cell adhesion and growth factor receptors. Additionally, altering PTP expression levels or activity impairs neuronal behavior. In this review we outline what is currently known about the role of PTPs in development, differentiation and neuronal physiology.
在神经元发育过程中，细胞通过与基于蛋白质酪氨酸磷酸化和去磷酸化的信号转导机制偶联的细胞表面受体，对多种环境信号作出反应。受体酪氨酸激酶和非受体酪氨酸激酶受到了广泛关注；然而，在过去几年中，受体（与质膜相关）和非受体蛋白酪氨酸磷酸酶（PTPs）也已被证明在神经系统发育中发挥重要作用。在许多情况下，PTPs具有激发性的分布模式，或者已被证明与特定的细胞粘附和生长因子受体相关。此外，改变PTP的表达水平或活性会损害神经元行为。在这篇综述中，我们概述了目前已知的PTPs在发育、分化和神经元生理学中的作用。
