Moody W J
Department of Zoology, University of Washington, Seattle 98195-1800, USA.
J Neurobiol. 1998 Oct;37(1):97-109. doi: 10.1002/(sici)1097-4695(199810)37:1<97::aid-neu8>3.0.co;2-3.
Electrical activity participates in the development of the nervous system and comes in two general forms. Use-dependent or experience-driven activity occurs relatively late in development, and is important in events of terminal nervous system differentiation, such as stabilization of synaptic connections. Earlier in development, activity is spontaneous, occurring independently of normal sensory input and motor output. Spontaneous activity participates in many of the initial events of axon outgrowth, pruning of synaptic connections, and maturation of neuronal signaling properties. Despite its importance, the genesis of spontaneous activity is poorly understood. What is clear is that spontaneous activity must be regulated by the patterns with which voltage- and ligand-gated ion channels develop in individual neurons. This review explores how that regulation most likely occurs.
电活动参与神经系统的发育，有两种一般形式。依赖使用或经验驱动的活动在发育过程中相对较晚出现，在终末神经系统分化事件中很重要，比如突触连接的稳定。在发育早期，活动是自发的，独立于正常的感觉输入和运动输出而发生。自发活动参与轴突生长、突触连接修剪以及神经元信号特性成熟等许多初始事件。尽管其很重要，但自发活动的起源却知之甚少。清楚的是，自发活动必定受单个神经元中电压门控和配体门控离子通道发育模式的调控。本综述探讨了这种调控最可能是如何发生的。
