Dal-Ré R, García-Corbeira P, García-de-Lomas J
Medical Department, SmithKline Beecham Pharmaceuticals, Madrid, Spain.
J Med Virol. 2000 Apr;60(4):363-6.
A seroepidemiological study was conducted to assess the seroprevalence of hepatitis A (HAV) antibodies in the Spanish general population in 1992-93. A total of 2744 subjects (1337 men and 1437 women) in the 5-59 years age range were stratified by gender and age (5-12, 13-19, 20-29, 30-39, 40-49, 50-59 years). The presence of total anti-HAV antibodies was investigated using a commercial enzyme immunoassay. Fifty-five percent (95% CI: 53.5-57. 2%) of the subjects were positive for anti-HAV antibodies, the age-standardized anti-HAV prevalence being 65.4%. Prevalence of seropositive subjects increased with increasing age (chi(2) = 996, 17; P < 0.0001), being 11%, 25% and 54% for the 5-12, 13-19 and 20-29 age groups respectively. The results from this study showed a remarkable decline in seroprevalence rates among children, adolescents and young adults. The large number of susceptible subjects in these groups of the population has public health implications in a country with intermediate HAV prevalence.
1992 - 1993年开展了一项血清流行病学研究，以评估西班牙普通人群中甲型肝炎（HAV）抗体的血清流行率。共有2744名年龄在5 - 59岁之间的受试者（1337名男性和1437名女性）按性别和年龄（5 - 12岁、13 - 19岁、20 - 29岁、30 - 39岁、40 - 49岁、50 - 59岁）进行分层。使用商用酶免疫测定法检测总抗-HAV抗体的存在情况。55%（95%置信区间：53.5 - 57.2%）的受试者抗-HAV抗体呈阳性，年龄标准化的抗-HAV流行率为65.4%。血清阳性受试者的流行率随年龄增长而增加（χ² = 996.17；P < 0.0001），5 - 12岁、13 - 19岁和20 - 29岁年龄组的流行率分别为11%、25%和54%。本研究结果显示，儿童、青少年和年轻人中的血清流行率显著下降。在一个甲型肝炎流行率中等的国家，这些人群中大量的易感者具有公共卫生意义。
