Myhrer T
Division for Environmental Toxicology, Norwegian Defence Research Establishment, Kjeller, Norway.
Neurobiol Learn Mem. 2000 Jan;73(1):68-78. doi: 10.1006/nlme.1999.3918.
The hippocampal region along with rhinal structures seems to support learning and memory in an important manner. Structures adjacent to the rhinal fissure in the rat have recently been suggested to be divided into the perirhinal and postrhinal cortices. Some effects of perirhinal lesions on cognitive processing are known, whereas effects of postrhinal lesions appear to be unknown. The purpose of the present study was to examine the relative effects of perirhinal and postrhinal lesions in a three-choice visual discrimination test. The results show that both types of lesions impaired acquisition of the task, but only perirhinal lesions impeded subsequent retention. Because the initial phase of acquisition was unaffected by both lesions, it is suggested that the deficits observed may be of mnemonic nature. The apparent differential involvement of the perirhinal cortex and postrhinal cortex in cognition may be associated with differences in anatomical connectivity among these structures.
海马体区域以及鼻周结构似乎以一种重要的方式支持学习和记忆。最近有人提出，大鼠中与鼻裂相邻的结构可分为嗅周皮质和鼻后皮质。嗅周损伤对认知加工的一些影响是已知的，而鼻后损伤的影响似乎尚不清楚。本研究的目的是在三项选择视觉辨别测试中检验嗅周和鼻后损伤的相对影响。结果表明，两种类型的损伤都损害了任务的习得，但只有嗅周损伤阻碍了后续的记忆保持。由于习得的初始阶段不受两种损伤的影响，因此表明观察到的缺陷可能具有记忆性质。嗅周皮质和鼻后皮质在认知中明显不同的参与程度可能与这些结构之间解剖连接性的差异有关。
