Myhrer T, Wangen K
Norwegian Defence Research Establishment, Division for Environmental Toxicology, Kjeller, Norway.
Neurobiol Learn Mem. 1996 May;65(3):244-52. doi: 10.1006/nlme.1996.0029.
Damage to the temporal cortex (TC), the lateral entorhinal cortex (LEC), or their interconnections has disruptive effects on visual memory. The fiber connections between TC and LEC are relayed in the perirhinal cortex (PC) or in the adjacent white matter of PC. PC seems to make up a particularly important structure for mnemonic processing. The purpose of the present study was to examine whether selective PC lesions might affect retroactive or proactive memory, since TC/LEC transections can cause both retrograde and anterograde amnesia. The results show that both PC and TC/LEC lesions impair retroactive memory to similar degrees (Experiment 1). However, PC lesions yielded a slightly stronger impairment of both acquisition and retention in the proactive paradigm than TC/LEC lesions (Experiment 2). These findings give support to the notion that PC plays an important role in formation of memory.
颞叶皮质（TC）、外侧内嗅皮质（LEC）或它们之间的连接受损会对视觉记忆产生破坏作用。TC和LEC之间的纤维连接在嗅周皮质（PC）或PC相邻的白质中中继。PC似乎构成了记忆处理中一个特别重要的结构。本研究的目的是检验选择性PC损伤是否会影响逆行性或前瞻性记忆，因为TC/LEC横断会导致逆行性和顺行性失忆。结果表明，PC和TC/LEC损伤对逆行性记忆的损害程度相似（实验1）。然而，在主动范式中，PC损伤对习得和保持的损害略强于TC/LEC损伤（实验2）。这些发现支持了PC在记忆形成中起重要作用的观点。
