Koorengevel K M, Beersma D G, Gordijn M C, den Boer J A, van den Hoofdakker R H
Department of Biological Psychiatry, Psychiatric University Clinic, Groningen, The Netherlands.
Biol Psychiatry. 2000 Feb 15;47(4):355-8. doi: 10.1016/s0006-3223(99)00225-5.
It has been suggested that certain abnormalities (e.g., in phase or amplitude) of the circadian pacemaker underlie seasonal affective disorder.
One male seasonal affective disorder patient (blind to the study design) participated in two 120-hour forced desynchrony experiments and was subjected to six 20-hour days, once during a depressive episode and once after recovery. Core body temperature was continuously measured. During wakefulness, the Adjective Mood Scale was completed at 2-hour intervals.
Sleep-wake as well as pacemaker-related variations of mood were found, both when the subject was depressed and when he was euthymic. Compared with recovery, during the depressive episode the circadian temperature minimum and the circadian mood variation showed phase delays of approximately 1 and 2 hours, respectively.
The data of this first seasonal affective disorder patient, participating in forced desynchrony experiments, may indicate a phase delay of the circadian pacemaker during a seasonal affective disorder episode.
有人提出，昼夜节律起搏器的某些异常（如相位或振幅方面）是季节性情感障碍的基础。
一名男性季节性情感障碍患者（对研究设计不知情）参与了两项120小时的强制非同步实验，经历了六个20小时的白昼，一次是在抑郁发作期间，一次是在康复后。连续测量核心体温。在清醒期间，每隔2小时完成一次形容词情绪量表。
无论是在患者抑郁时还是心境正常时，都发现了睡眠 - 觉醒以及与起搏器相关的情绪变化。与康复期相比，在抑郁发作期间，昼夜体温最低点和昼夜情绪变化分别出现了约1小时和2小时的相位延迟。
这名参与强制非同步实验的首例季节性情感障碍患者的数据可能表明，在季节性情感障碍发作期间，昼夜节律起搏器存在相位延迟。
