Eastman C I, Gallo L C, Lahmeyer H W, Fogg L F
Biological Rhythms Research Laboratory, Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL 60612.
Biol Psychiatry. 1993 Aug 15;34(4):210-20. doi: 10.1016/0006-3223(93)90074-n.
Circadian rhythm abnormalities have been implicated in winter seasonal affective disorder. We examined the circadian temperature rhythm of 22 patients with winter depression and 10 normal controls who had participated in various high-intensity light treatment experiments. We did not find abnormalities in the baseline phase or amplitude of the temperature rhythm in patients compared to controls. Nor did we find abnormalities in the phase-shifting response to morning light. There was some evidence that the "phase-delayed" half of the patients responded poorly to phase advances produced by morning light, whereas the "phase-advanced" half of the patients responded poorly when their rhythms delayed. However, the antidepressant responses during the best week (week of lowest depression score) were unrelated to temperature rhythm phase shifts. In general, there was not strong support for a relationship between circadian rhythms changes and antidepressant response.
昼夜节律异常与冬季季节性情感障碍有关。我们研究了22例冬季抑郁症患者和10名正常对照者的昼夜体温节律，这些对照者参与了各种高强度光照治疗实验。与对照组相比，我们未发现患者体温节律的基线相位或振幅存在异常。我们也未发现对早晨光照的相位转移反应存在异常。有一些证据表明，“相位延迟”的那一半患者对早晨光照引起的相位提前反应不佳，而“相位提前”的那一半患者在其节律延迟时反应不佳。然而，最佳一周（抑郁评分最低的一周）期间的抗抑郁反应与体温节律相位变化无关。总体而言，昼夜节律变化与抗抑郁反应之间的关系并未得到有力支持。
