类风湿关节炎中的继发性淀粉样变性。29例患者的临床研究
[Secondary amyloidosis in rheumatoid arthritis. A clinical study of 29 patients].
作者信息
Fiter Aresté J, Nolla Solé J M, Gómez Vaquero C, Valverde García J, Roig Escofet D
机构信息
Servicio de Reumatología, Hospital Prínceps d'Espanya, Barcelona.
出版信息
An Med Interna. 1999 Dec;16(12):615-9.
BACKGROUND
To study the clinical features, outcome and response to therapy in 29 cases of rheumatoid arthritis (RA) with secondary amyloidosis (AA).
PATIENTS AND METHOD
Twenty-nine patients with RA and AA who were diagnosed during 11 years.
RESULTS
The mean age and the mean duration of RA were 63 +/- 12 years and 15 +/- 7 years respectively. The most common initial clinical feature was renal involvement (83%). Nineteen patients were treated with methotrexate. The mean survival time was 42 +/- 8 months. Eleven patients (38%) have deceased.
CONCLUSION
Our data confirms that AA in RA is a serious complication with a bleak prognosis. A normal renal function is a good prognosis indicator.
背景
研究29例类风湿关节炎（RA）继发淀粉样变性（AA）患者的临床特征、预后及治疗反应。
患者与方法
29例在11年间确诊为RA和AA的患者。
结果
RA的平均年龄和平均病程分别为63±12岁和15±7年。最常见的初始临床特征是肾脏受累（83%）。19例患者接受了甲氨蝶呤治疗。平均生存时间为42±8个月。11例患者（38%）已死亡。
结论
我们的数据证实，RA中的AA是一种预后不佳的严重并发症。肾功能正常是预后良好的指标。
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