Behrens S, Grundmann-Kollmann M, Schiener R, Peter R U, Kerscher M
Department of Dermatology, University of Ulm, Germany.
J Am Acad Dermatol. 2000 Mar;42(3):493-5. doi: 10.1016/s0190-9622(00)90225-1.
Narrow-band UVB (311 nm) phototherapy offering an emission spectrum closely conforming to the peak of the action spectrum for clearing psoriasis has significantly improved phototherapy for psoriasis. Because the majority of the commonly used topical therapies in treatment of psoriasis have limitations, a need for new topical agents remains. Tazarotene has been shown to be efficacious in plaque-type psoriasis. Combination of narrow-band UVB with topical agents has been shown to enhance efficacy of both treatment modalities.
We attempted to evaluate the efficacy of narrow-band UVB phototherapy in combination with topical tazarotene.
Ten patients with stable plaque psoriasis were treated with narrow-band UVB. In addition, topical tazarotene 0.05% was applied once daily to one side of the body. The follow-up period was 4 weeks. Efficacy was assessed separately for both body halves by means of a modified Psoriasis Area and Severity Index (PASI).
Both treatment modalities notably reduced the PASI scores with values being significantly lower in skin areas treated with narrow-band UVB phototherapy in combination with topical tazarotene.
The addition of tazarotene to narrow-band UVB phototherapy promotes more effective, faster clearing of psoriasis compared with UVB (311 nm) monotherapy.
窄谱中波紫外线（311nm）光疗提供的发射光谱与清除银屑病的作用光谱峰值紧密相符，显著改善了银屑病的光疗效果。由于治疗银屑病的大多数常用外用疗法都有局限性，因此仍需要新的外用药物。他扎罗汀已被证明对斑块型银屑病有效。窄谱中波紫外线与外用药物联合使用已被证明可提高两种治疗方式的疗效。
我们试图评估窄谱中波紫外线光疗联合外用他扎罗汀的疗效。
10例稳定期斑块状银屑病患者接受窄谱中波紫外线治疗。此外，0.05%的外用他扎罗汀每天在身体一侧涂抹一次。随访期为4周。通过改良的银屑病面积和严重程度指数（PASI）分别评估身体两侧的疗效。
两种治疗方式均显著降低了PASI评分，在联合使用窄谱中波紫外线光疗和外用他扎罗汀治疗的皮肤区域，评分显著更低。
与窄谱中波紫外线（311nm）单一疗法相比，在窄谱中波紫外线光疗中添加他扎罗汀可更有效、更快地清除银屑病。
