Hirai K, Seki T
Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan.
Neuropeptides. 2000 Feb;34(1):18-24. doi: 10.1054/npep.1999.0781.
We analysed the level of cerebrospinal fluid (CSF) somatostatin in children with febrile seizures and epilepsy. In the febrile seizure group (n = 23), the somatostatin level was 83.9 +/- 11.2 pg/ml, which was significantly higher than that of age-matched controls. CSF samples obtained within 3 h of the last seizure had higher somatostatin levels (106.1 +/- 12.4 pg/ml;n = 14) than did the CSF obtained after 3 h (49.4 +/- 15.6 pg/ml;n = 9). The mean somatostatin level in the epilepsy group was 35.3 +/- 4.3 pg/ml (n = 34), and was distributed as follows: 27.6 +/- 3.6 pg/ml in the idiopathic generalized epilepsy group (n = 16), 44.0 +/- 9.4 pg/ml in the symptomatic generalized epilepsy group (n = 13), and 37.2 +/- 10.1 pg/ml in the partial epilepsy group (n = 5). The levels in each group were significantly higher than those in age-matched controls. Somatostatin is a hypothalamic tetradecapeptide with excitatory effects on neurons in children with febrile seizures and epilepsy. The finding that patients with convulsive disease had elevated levels of CSF somatostatin suggests that somatostatin release is somehow related to seizure activity. It remains to be determined whether this is due to increased release from over-active excitatory neurons or leakage from damaged or anoxic neurons, secondary to seizure activity.
我们分析了热性惊厥和癫痫患儿脑脊液（CSF）中生长抑素的水平。在热性惊厥组（n = 23）中，生长抑素水平为83.9±11.2 pg/ml，显著高于年龄匹配的对照组。在最后一次惊厥发作后3小时内采集的脑脊液样本中生长抑素水平（106.1±12.4 pg/ml；n = 14）高于3小时后采集的脑脊液（49.4±15.6 pg/ml；n = 9）。癫痫组的生长抑素平均水平为35.3±4.3 pg/ml（n = 34），分布如下：特发性全身性癫痫组为27.6±3.6 pg/ml（n = 16），症状性全身性癫痫组为44.0±9.4 pg/ml（n = 13），部分性癫痫组为37.2±10.1 pg/ml（n = 5）。每组的水平均显著高于年龄匹配的对照组。生长抑素是一种下丘脑十四肽，对热性惊厥和癫痫患儿的神经元具有兴奋作用。惊厥性疾病患者脑脊液中生长抑素水平升高的发现表明，生长抑素的释放与癫痫活动在某种程度上相关。这是否是由于过度活跃的兴奋性神经元释放增加，还是继发于癫痫活动的受损或缺氧神经元的渗漏，仍有待确定。
