肠道上皮细胞的抗原加工与呈递——极性与复杂性
Antigen processing and presentation by intestinal epithelial cells - polarity and complexity.
作者信息
Hershberg R M, Mayer L F
机构信息
Divisions of Gastroenterology and Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
出版信息
Immunol Today. 2000 Mar;21(3):123-8. doi: 10.1016/s0167-5699(99)01575-3.
The mechanisms by which gut-associated lymphoid tissue (GALT) maintains a balance between oral tolerance and active immune response in the face of exposure to high antigen concentrations remains a central question in mucosal immunity. Here, Robert Hershberg and colleagues discuss the evidence that human intestinal epithelial cells function as antigen-presenting cells (APCs) capable of regulating T-cell responses in the intestinal mucosa
面对高抗原浓度时，肠道相关淋巴组织（GALT）在口服耐受和主动免疫反应之间维持平衡的机制仍是黏膜免疫中的核心问题。在此，罗伯特·赫什伯格及其同事讨论了相关证据，即人类肠道上皮细胞作为抗原呈递细胞（APC），能够调节肠道黏膜中的T细胞反应。
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