Millar E K, Waldron S, Spencer A, Braye S
Department of Anatomical Pathology, John Hunter Hospital, Hunter Region Mail Centre, Lambton, Australia.
J Clin Pathol. 1999 Nov;52(11):849-50. doi: 10.1136/jcp.52.11.849.
A 72 year old woman presented with swelling of the right lobe of her thyroid gland. Fine needle aspiration and flow cytometry showed a clonal population of B cells expressing CD10 and a diagnosis of follicle centre cell lymphoma was made. Subsequent excision of the thyroid showed the typical histological features of a marginal zone non-Hodgkin lymphoma. Polymerase chain reaction showed no evidence of t (14;18). Immunohistochemistry confirmed CD10 positivity and LN1 (CDw75) expression. This is only the second report of aberrant expression of CD 10 by a marginal zone lymphoma.
一名72岁女性因甲状腺右叶肿大就诊。细针穿刺及流式细胞术显示一群表达CD10的B细胞克隆，诊断为滤泡中心细胞淋巴瘤。随后的甲状腺切除术显示为边缘区非霍奇金淋巴瘤的典型组织学特征。聚合酶链反应未发现t(14;18)证据。免疫组化证实CD10阳性及LN1(CDw75)表达。这是边缘区淋巴瘤异常表达CD10的第二篇报道。
