心血管系统中一氧化氮合酶的分子调控
Molecular control of nitric oxide synthases in the cardiovascular system.
作者信息
Papapetropoulos A, Rudic R D, Sessa W C
机构信息
Department of Pharmacology, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06536, USA.
出版信息
Cardiovasc Res. 1999 Aug 15;43(3):509-20. doi: 10.1016/s0008-6363(99)00161-3.
Abstract
Nitric oxide plays an important role in cardiovascular homeostasis. In this review, the regulation of the three nitric oxide synthase isoforms in the cardiovascular system are examined at molecular and cellular levels. In addition, recent information gleaned from the use of NOS knockout mice are discussed.
摘要
一氧化氮在心血管稳态中发挥着重要作用。在这篇综述中，我们在分子和细胞水平上研究了心血管系统中三种一氧化氮合酶同工型的调节机制。此外，还讨论了从一氧化氮合酶基因敲除小鼠的研究中获得的最新信息。
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