Dietzsch E, Albrecht C F, Parker M I
Department of Medical Biochemistry, Faculty of Health Sciences, University of Cape Town, Observatory, South Africa.
IUBMB Life. 1999 Sep;48(3):321-5. doi: 10.1080/713803515.
The effect of rooperol on type I collagen synthesis in normal skin and lung fibroblasts and cell growth in normal and transformed fibroblasts was investigated. Low concentrations of rooperol selectively inhibited the growth of transformed cells while stimulating collagen synthesis in normal fibroblasts. Elevated collagen synthesis and deposition could impede tumour cell invasion and metastasis, implying that rooperol may be useful as an antimetastatic agent in the treatment of cancer.
研究了鲁珀醇对正常皮肤和肺成纤维细胞中I型胶原蛋白合成以及对正常和转化成纤维细胞生长的影响。低浓度的鲁珀醇选择性地抑制转化细胞的生长，同时刺激正常成纤维细胞中的胶原蛋白合成。胶原蛋白合成和沉积的增加可能会阻碍肿瘤细胞的侵袭和转移，这意味着鲁珀醇可能作为一种抗转移剂用于癌症治疗。
