Pop M, Payette Y
Michel Pop Clinics, Montreal, Quebec, Canada.
Ophthalmology. 2000 Feb;107(2):251-7. doi: 10.1016/s0161-6420(99)00043-3.
Photorefractive keratectomy (PRK) and laser in situ keratomileusis (LASIK) outcomes were compared at 1, 3, 6, and 12 months after surgery.
Retrospective, nonrandomized, comparative study.
One hundred seven LASIK-treated eyes (58 patients) and 107 PRK-treated eyes (91 patients) having myopia between -1 and -9.50 diopters (D). All LASIK-treated eyes were analyzed retrospectively and matched with PRK-treated eyes having sphere within +/-0.25 D, +/-1 D of cylinder, and +/-7 years of age.
For PRK and LASIK, the refractive surgery was performed with the slit-scanning excimer laser Nidek EC-5000, (Nidek Co. Tokyo, Japan)
Manifest refraction, best-spectacle and uncorrected Snellen visual acuity, haze, halos, and keratometry were evaluated before surgery and up to 12 months after surgery.
Seventy percent of eyes were evaluated at the 12-month postoperative exam. Of these eyes, 83% of LASIK cases and 86% of PRK cases had uncorrected visual acuities of 20/20 or better. Refractions within +/-0.5 D represented 78% of the LASIK eyes and 83% of the PRK eyes at that follow-up. Patients who underwent LASIK reported halos twice as often as patients who underwent PRK using a subjective scale. The odds ratio of high halos for LASIK versus PRK was 3.50 (95% confidence interval, 1.89-6.46; P<0.0001). At 1 month after surgery, 64% of the LASIK eyes were within +/-0.50 D compared with 77% of the PRK eyes. No eye lost 2 Snellen lines of best corrected visual acuity at 6 or 12 months after surgery. Ten PRK eyes (9.3%) and three LASIK eyes (2.8%) were retreated.
PRK and LASIK achieved equal refractive outcomes at all postoperative follow-ups, but LASIK patients were twice as likely to experience halos.
比较准分子激光角膜切削术（PRK）和准分子原位角膜磨镶术（LASIK）术后1、3、6和12个月时的手术效果。
回顾性、非随机对照研究。
107只接受LASIK治疗的眼睛（58例患者）和107只接受PRK治疗的眼睛（91例患者），近视度数在-1至-9.50屈光度（D）之间。所有接受LASIK治疗的眼睛均进行回顾性分析，并与球镜度数在±0.25 D、柱镜度数在±1 D以内且年龄相差±7岁的接受PRK治疗的眼睛进行匹配。
对于PRK和LASIK，均使用裂隙扫描准分子激光Nidek EC-5000（日本东京尼德克公司）进行屈光手术。
在手术前及术后长达12个月的时间内，评估显验光、最佳矫正视力和未矫正的斯内伦视力、角膜 haze、光晕和角膜曲率。
70%的眼睛接受了术后12个月的检查。在这些眼睛中，83%的LASIK病例和86%的PRK病例未矫正视力达到20/20或更好。在该随访时，屈光度数在±0.5 D以内的眼睛中，LASIK组占78%，PRK组占83%。接受LASIK治疗的患者报告光晕的频率是接受PRK治疗患者的两倍（采用主观评分）。LASIK组与PRK组相比，高光晕的优势比为3.50（95%置信区间，1.89 - 6.46；P < 0.0001）。术后1个月时，64%的LASIK眼睛屈光度数在±0.50 D以内，而PRK眼睛为77%。术后6个月或12个月时，没有眼睛的最佳矫正视力下降2行斯内伦视力。10只PRK眼睛（9.3%）和3只LASIK眼睛（2.8%）接受了再次手术。
在所有术后随访中，PRK和LASIK的屈光效果相当，但LASIK患者出现光晕的可能性是PRK患者的两倍。
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