Beausencourt E, Remky A, Elsner A E, Hartnett M E, Trempe C L
Schepens Eye Research Institute, Boston, Massachusetts 02114-2500, USA.
Ophthalmology. 2000 Feb;107(2):375-85. doi: 10.1016/s0161-6420(99)00056-1.
To perform three-dimensional, noninvasive, quantitative analysis of cystoid macular edema and macular cysts using infrared scanning laser tomography and to correlate findings with visual acuity (VA) as a basis for interventional studies.
Cross-sectional, nonrandomized study.
Seventeen patients (29-86 years of age) with macular cysts associated with a broad spectrum of diseases.
Confocal infrared imaging with scanning laser tomography with the TopSS (790 nm) (Laser Diagnostic Technologies, San Diego, CA) with digitized images was used to perform three-dimensional, quantitative analysis of cysts in the central 5 degrees of the macula.
Measurements of macular cyst number, area, volume, depth, slope, height of the surrounding macular elevation, and correlation with VA.
Scanning laser tomography detected macular cysts in all patients. The number per patient ranged from 1 through 15. Cysts were accompanied by surrounding macular elevation in 16 patients (mean macular height, 216 microm). The area covered by cysts in the central 5 degrees was 0.087 to 0.969 mm2, and volume was 0.007 to 0.549 mm3. Visual acuity was significantly poorer in patients with greater cyst area (P = 0.0007), cyst volume (P = 0.0009), macular thickening (P = 0.0002), and cyst depth (P = 0.0013). Cyst number, average slope, and maximum slope, however, did not correlate significantly with VA. Grouping of macular cysts according to macular height and average cyst depth revealed that cysts in a more thickened retina were significantly deeper, had steeper slopes, and corresponded to worse VA. Macular height and average cyst depth were highly associated with each other, suggesting that in eyes with surrounding macular edema, cysts were deeper and may reflect more widespread tissue destruction. Individual confocal tomographic images provided additional information. Neither ophthalmoscopy nor fluorescein angiography delineated features such as retinal folds that suggested vitreous traction or changes in deeper layers that suggested occult choroidal new vessels.
Infrared scanning laser tomography is a rapid and noninvasive imaging method that provides quantitative analysis of macular cysts in addition to qualitative information not seen clinically. Because poor VA is related to severe involvement of the central retina, scanning laser tomography could provide an objective outcome measure for interventional studies.
使用红外扫描激光断层扫描技术对黄斑囊样水肿和黄斑囊肿进行三维、无创、定量分析，并将结果与视力（VA）相关联，作为干预性研究的基础。
横断面、非随机研究。
17例（年龄29 - 86岁）患有与多种疾病相关的黄斑囊肿的患者。
使用TopSS（790 nm）（激光诊断技术公司，加利福尼亚州圣地亚哥）的扫描激光断层扫描共聚焦红外成像及数字化图像，对黄斑中心5度范围内的囊肿进行三维定量分析。
测量黄斑囊肿的数量、面积、体积、深度、斜率、周围黄斑隆起的高度，并与视力进行相关性分析。
扫描激光断层扫描在所有患者中均检测到黄斑囊肿。每位患者的囊肿数量为1至15个。16例患者的囊肿伴有周围黄斑隆起（平均黄斑高度为216微米）。中心5度范围内囊肿覆盖的面积为(0.087)至(0.969)平方毫米，体积为(0.007)至(0.549)立方毫米。囊肿面积较大（(P = 0.0007)）、囊肿体积较大（(P = 0.0009)）、黄斑增厚（(P = 0.0002)）以及囊肿深度较大（(P = 0.0013)）的患者，视力明显较差。然而，囊肿数量、平均斜率和最大斜率与视力无显著相关性。根据黄斑高度和平均囊肿深度对黄斑囊肿进行分组显示，视网膜增厚更明显的区域中的囊肿更深，斜率更陡，且对应更差的视力。黄斑高度和平均囊肿深度彼此高度相关，这表明在伴有周围黄斑水肿的眼中，囊肿更深，可能反映了更广泛的组织破坏。个体共聚焦断层扫描图像提供了额外信息。检眼镜检查和荧光素血管造影均未显示出提示玻璃体牵拉的视网膜褶皱或提示隐匿性脉络膜新生血管的深层变化等特征。
红外扫描激光断层扫描是一种快速、无创的成像方法，除了提供临床未见的定性信息外，还能对黄斑囊肿进行定量分析。由于视力差与中央视网膜的严重受累有关，扫描激光断层扫描可为干预性研究提供客观的观察指标。
