拉莫三嗪治疗期间体重稳定：32项研究综述。
Stable weight during lamotrigine therapy: a review of 32 studies.
作者信息
Devinsky O, Vuong A, Hammer A, Barrett P S
机构信息
Department of Neurology, New York University Medical Center, USA.
出版信息
Neurology. 2000 Feb 22;54(4):973-5. doi: 10.1212/wnl.54.4.973.
A side effect associated with the use of some antiepileptic drugs (AEDs) is change in body weight. To evaluate the effect of lamotrigine on body weight in adult patients with epilepsy, we conducted a retrospective review of data from 463 patients treated with lamotrigine in 32 clinical trials. Mean daily dose was 259 (+/-155) mg and duration of therapy was 318 (+/-87) days. The mean change in body weight was 0.5 (+/-5) kg. Lamotrigine was associated with stable body weight in patients with epilepsy.
使用某些抗癫痫药物（AEDs）会产生体重变化这一副作用。为评估拉莫三嗪对成年癫痫患者体重的影响，我们对32项临床试验中463例接受拉莫三嗪治疗的患者的数据进行了回顾性分析。平均日剂量为259（±155）mg，治疗时长为318（±87）天。体重的平均变化为0.5（±5）kg。拉莫三嗪与癫痫患者体重稳定有关。
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