Pitkänen O M, Vanhanen H, Pitkänen E
Hospital for Children and Adolescents, University Hospital, Helsinki, Finland.
Scand J Clin Lab Invest. 1999 Dec;59(8):607-12. doi: 10.1080/00365519950185094.
Serum mannose concentration increases in diabetic patients and correlates closely with blood glucose. In patients with glomerulonephritis, serum mannose and mannose/glucose ratio positively correlate with dyslipidemia and the extent of urinary protein excretion. We investigated whether changes in serum mannose mark subjects with features of metabolic syndrome, including obesity, hypertension, glucose intolerance, and dyslipidemia. The study comprised 20 patients with mean age of 68 (SD 11) years, body mass index 27.2 (SD 5.1) kg/m2, blood glucose 6.2 (SD 1.6) mmol/L, serum total cholesterol 6.3 (SD 1.2) mmol/L, triglyceride 2.0 (SD 0.08) mmol/L, uric acid 320 (SD 109) micromol/L, mannose 60.0 (SD 17) micromol/L, and mannose/glucose ratio 9.7 (SD 1.8) micromol/mmol. Serum mannose correlated with blood glucose (r=0.758, p=0.012), triglyceride (r=0.478, p=0.023), and HDL-cholesterol (r = approximately 0.427, p=0.022). Mannose/glucose ratio correlated with BMI (r=0.581, p=0.033), mannose (r=0.491, p=0.035), and uric acid (r=0.608, p=0.027). The rate of VLDL lipoprotein turnover may be instrumental in the regulation of serum mannose concentration. We conclude that an altered mannose metabolism is a novel consideration among the metabolic abnormalities in the metabolic syndrome.
糖尿病患者血清甘露糖浓度升高，且与血糖密切相关。在肾小球肾炎患者中，血清甘露糖及甘露糖/葡萄糖比值与血脂异常及尿蛋白排泄程度呈正相关。我们研究了血清甘露糖的变化是否标志着具有代谢综合征特征的受试者，这些特征包括肥胖、高血压、葡萄糖不耐受和血脂异常。该研究纳入了20名患者，平均年龄68（标准差11）岁，体重指数27.2（标准差5.1）kg/m²，血糖6.2（标准差1.6）mmol/L，血清总胆固醇6.3（标准差1.2）mmol/L，甘油三酯2.0（标准差0.08）mmol/L，尿酸320（标准差109）微摩尔/升，甘露糖60.0（标准差17）微摩尔/升，甘露糖/葡萄糖比值9.7（标准差1.8）微摩尔/毫摩尔。血清甘露糖与血糖（r = 0.758，p = 0.012）、甘油三酯（r = 0.478，p = 0.023）及高密度脂蛋白胆固醇（r约为0.427，p = 0.022）相关。甘露糖/葡萄糖比值与体重指数（r = 0.581，p = 0.033）、甘露糖（r = 0.491，p = 0.035）及尿酸（r = 0.608，p = 0.027）相关。极低密度脂蛋白周转率可能有助于调节血清甘露糖浓度。我们得出结论，甘露糖代谢改变是代谢综合征代谢异常中的一个新的考虑因素。
